ELF4

Across TCGA pan-cancer cohorts, ELF4 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ELF4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ELF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ELF4 is over-expressed in tumor, although a few such as COAD and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where ELF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ELF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.315	<.001	12	view →
KIRC	Female	All	+1.166	<.001	12	view →
KIRP	All	III,IV	+1.174	<.001	11	view →
THCA	Male	All	+1.103	<.001	10	view →
STAD	Male	II,III,IV	+1.255	<.001	6	view →
BRCA	All	III,IV	+0.610	<.001	6	view →
CHOL	Female	All	+3.710	<.001	5	view →
BLCA	All	III,IV	+1.016	.005	5	view →
ESCA	All	II,III,IV	+1.545	.001	4	view →
LIHC	Female	All	+0.763	.013	4	view →
KICH	All	All	+0.519	.029	4	view →
LUSC	Male	All	+0.462	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ELF4–HNSC

Open the HNSC breakdown →