ELF3

Across TCGA cell cohorts, ELF3 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELF3-associated genes across cancer lineages are TLR8, SMCP, and DNAI2. Each is linked with ELF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELF3-to-partner and partner-to-ELF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLR8 grouped by ELF3-low versus ELF3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELF3→partner) and Y-score (partner→ELF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TLR8 →	+0.015	+3.584	<.001	.005	3	1
URINARY_TRACT	SMCP →	+0.094	+3.807	.005	.005	3	1
URINARY_TRACT	DNAI2 →	+0.112	+3.523	.001	.009	3	1
URINARY_TRACT	ATP4B →	+0.055	+3.584	<.001	.005	3	1
URINARY_TRACT	LCE1C →	+0.157	+4.050	<.001	.002	3	1
URINARY_TRACT	LPA →	+0.115	+3.643	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

TLR8 by ELF3 expression — URINARY_TRACT

Explore this box plot interactively →