ELDR

Across TCGA patient cohorts, ELDR RNA expression is significantly associated with the go_rna of many other GO terms, with 6,821 significant associations in total. THYM shows the largest number of these associations.

The most reproducible ELDR-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Regulation of DNA replication, and Spindle elongation. Each is linked with ELDR in more than 17 cancer types. Because this analysis shows association rather than direction, both ELDR-to-partner and partner-to-ELDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by ELDR-low versus ELDR-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ELDR→partner) and Y-score (partner→ELDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	DNA integrity checkpoint signaling →	+0.076	+0.120	<.001	<.001	3	18
STAD	Regulation of DNA replication →	+0.074	+0.137	<.001	<.001	3	18
ESCA	Spindle elongation →	+0.126	+0.181	<.001	<.001	3	17
STAD	Meiotic cell cycle →	+0.048	+0.142	<.001	<.001	2	18
SARC	Microtubule organizing center localization →	+0.072	+0.122	<.001	<.001	3	17
STAD	DNA replication initiation →	+0.063	+0.099	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,821 associations by consensus.

DNA integrity checkpoint signaling by ELDR expression — STAD

Explore this box plot interactively →