ELAC2

Across TCGA patient cohorts, ELAC2 mutation is significantly associated with the RNA expression of many other genes, with 2,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELAC2-associated genes across cancer lineages are RPL23AP82, NDUFB6, and NKD2. Each is linked with ELAC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ELAC2-to-partner and partner-to-ELAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by ELAC2-low versus ELAC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELAC2→partner) and Y-score (partner→ELAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP82 →	+0.575	+3.488	.001	.002	3	3
UCEC	NDUFB6 →	+0.412	+2.595	<.001	<.001	3	3
UCEC	NKD2 →	-0.903	-1.999	<.001	<.001	3	3
UCEC	LSM3 →	+0.471	+2.949	<.001	<.001	3	2
SKCM	POTEJ →	+0.040	+2.928	.001	.001	3	2
SKCM	ANXA2P2 →	+0.734	+3.220	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

RPL23AP82 by ELAC2 expression — SKCM

Explore this box plot interactively →