ELAC2

Across TCGA patient cohorts, ELAC2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELAC2-associated genes across cancer lineages are MSH6, YAP, and ERK2. Each is linked with ELAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELAC2-to-partner and partner-to-ELAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by ELAC2-low versus ELAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELAC2→partner) and Y-score (partner→ELAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.457	-1.906	<.001	.014	3	2
SKCM	YAP →	+0.383	+3.012	<.001	.018	3	2
UCEC	ERK2 →	+0.185	+2.906	.004	.001	3	2
UCEC	JNK2 →	+0.247	+1.874	<.001	.002	3	2
UCEC	STAT3_pY705 →	-0.253	-1.990	.003	.009	3	2
UCEC	ATM →	-0.550	-2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MSH6 by ELAC2 expression — UCEC

Explore this box plot interactively →