ELAC2

Across TCGA cell cohorts, ELAC2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELAC2-associated genes across cancer lineages are MBD3L5, GFRA4, and SLCO1C1. Each is linked with ELAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELAC2-to-partner and partner-to-ELAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L5 grouped by ELAC2-low versus ELAC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELAC2→partner) and Y-score (partner→ELAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MBD3L5 →	+0.024	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.356	+3.772	.005	.003	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2C →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MBD3L5 by ELAC2 expression — SKIN

Explore this box plot interactively →