EIF6

Across TCGA pan-cancer cohorts, EIF6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EIF6 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EIF6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EIF6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where EIF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.736	0.940	.001	27	view →
LSCC	DFS	Quartile	All	0.846	0.529	.006	7	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	4	view →
LUAD	OS	Median	All	0.999	0.891	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EIF6–CCRCC (OS)

Open the CCRCC breakdown →