EIF6

Across TCGA pan-cancer cohorts, EIF6 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EIF6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EIF6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EIF6 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

COAD, LUAD, and CCRCC are the cancer types where EIF6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.411	<.001	11	view →
LUAD	Female	II,III,IV	+0.518	<.001	9	view →
CCRCC	Male	III,IV	+0.331	<.001	9	view →
LSCC	Male	III,IV	+0.486	<.001	8	view →
HNSC	Male	All	−0.206	.003	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

EIF6–COAD

Open the COAD breakdown →