EIF6

Across TCGA patient cohorts, EIF6 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF6-associated genes across cancer lineages are PI3K-p85, 14-3-3_beta, and eEF2. Each is linked with EIF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF6-to-partner and partner-to-EIF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by EIF6-low versus EIF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF6→partner) and Y-score (partner→EIF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.253	+2.817	.036	.036	3	1
UCEC	14-3-3_beta →	-0.137	-2.986	.018	.037	2	1
UCEC	eEF2 →	+0.412	+3.000	.046	.037	2	1
UCEC	p90 RSK →	+0.219	+2.817	.047	.036	2	1
UCEC	Shc_pY317 →	-0.194	-3.000	.027	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PI3K-p85 by EIF6 expression — UCEC

Explore this box plot interactively →