EIF6

Across TCGA cell cohorts, EIF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,445 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EIF6-associated GO terms across cancer lineages are Regulation of centriole-centriole cohesion, IRE1-mediated unfolded protein response, and Positive regulation of cell cycle checkpoint. Each is linked with EIF6 in more than 9 cancer types. Because this analysis shows association rather than direction, both EIF6-to-partner and partner-to-EIF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centriole-centriole cohesion grouped by EIF6-low versus EIF6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF6→partner) and Y-score (partner→EIF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of centriole-centriole cohesion →	+0.126	+0.798	<.001	<.001	3	10
STOMACH	IRE1-mediated unfolded protein response →	+0.179	+1.038	<.001	<.001	3	10
BONE	Positive regulation of cell cycle checkpoint →	+0.126	+0.574	.006	.007	3	9
CNS	Sarcomere organization →	+0.233	+0.572	<.001	.006	3	9
KIDNEY	Secretory granule organization →	+0.073	+0.647	.001	.006	3	9
URINARY_TRACT	Spliceosomal tri-snRNP complex assembly →	+0.097	+0.734	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,445 associations by consensus.

Regulation of centriole-centriole cohesion by EIF6 expression — BREAST

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