EIF5B

Across TCGA patient cohorts, EIF5B mutation is significantly associated with the RNA expression of many other genes, with 2,265 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF5B-associated genes across cancer lineages are AGGF1P9, PEF1, and GLOD4. Each is linked with EIF5B in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF5B-to-partner and partner-to-EIF5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGGF1P9 grouped by EIF5B-low versus EIF5B-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5B→partner) and Y-score (partner→EIF5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	AGGF1P9 →	+0.050	+5.103	<.001	.004	3	3
UCEC	PEF1 →	+0.251	+3.545	.007	.002	3	3
STAD	GLOD4 →	+0.460	+3.182	.001	.009	3	3
UCEC	POLR2G →	+0.316	+3.648	.005	.001	3	3
UCEC	ATOH8 →	-0.565	-1.716	.007	.004	3	3
STAD	TYMS →	+0.981	+3.618	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,265 associations by consensus.

AGGF1P9 by EIF5B expression — KIRP

Explore this box plot interactively →