EIF5B

Across TCGA cell cohorts, EIF5B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,698 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF5B-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, Maturation of SSU-rRNA, and DNA-templated DNA replication. Each is linked with EIF5B in more than 13 cancer types. Because this analysis shows association rather than direction, both EIF5B-to-partner and partner-to-EIF5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by EIF5B-low versus EIF5B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5B→partner) and Y-score (partner→EIF5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.117	+0.766	.002	.001	3	14
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.118	+0.781	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.110	+0.614	<.001	.003	3	12
BLOOD_Myeloma	DNA replication initiation →	+0.154	+0.685	<.001	<.001	3	12
OVARY	RNA 5'-end processing →	+0.066	+0.642	.004	.001	3	12
BLOOD_Lymphoma	Ribosomal small subunit biogenesis →	+0.089	+0.650	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,698 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by EIF5B expression — LUNG_SCLC

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