EIF5B

Across TCGA cell cohorts, EIF5B mutation is significantly associated with the RNA expression of many other genes, with 1,557 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF5B-associated genes across cancer lineages are USP26, OTOR, and SHISAL2B. Each is linked with EIF5B in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF5B-to-partner and partner-to-EIF5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP26 grouped by EIF5B-low versus EIF5B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5B→partner) and Y-score (partner→EIF5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP26 →	+0.035	+2.192	.002	.001	3	2
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
PANCREAS	SHISAL2B →	+0.166	+4.011	<.001	.009	3	1
BLOOD_Myeloma	OR13C9 →	+0.152	+3.906	.003	.009	3	1
BLOOD_Myeloma	DMRTA2 →	+0.103	+3.906	.004	.009	3	1
BLOOD_Myeloma	ELOA3BP →	+0.060	+3.906	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,557 associations by consensus.

USP26 by EIF5B expression — LARGE_INTESTINE

Explore this box plot interactively →