EIF5A2

Across TCGA pan-cancer cohorts, EIF5A2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of EIF5A2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EIF5A2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EIF5A2 is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where EIF5A2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF5A2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.600	<.001	7	view →
LUAD	All	II,III,IV	−0.237	.001	7	view →
LSCC	Male	All	+0.474	<.001	6	view →
CCRCC	All	All	−0.174	.002	4	view →
PDAC	All	All	+0.432	.004	3	view →
OV	All	All	+0.471	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

EIF5A2–HNSC

Open the HNSC breakdown →