EIF5A

Across TCGA pan-cancer cohorts, EIF5A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EIF5A data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF5A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where EIF5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.867	0.708	.023	5	view →
LSCC	DFS	Tertile	II,III,IV	0.787	1.000	.030	4	view →
CCRCC	DFS	Quartile	III,IV	0.909	0.579	.036	3	view →
LUAD	DFS	Quartile	All	1.000	0.626	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EIF5A–HNSC (DFS)

Open the HNSC breakdown →