EIF5

Across TCGA patient cohorts, EIF5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF5-associated genes across cancer lineages are ATM, HER3_pY1289, and JNK2. Each is linked with EIF5 in more than 3 cancer types. Because this analysis shows association rather than direction, both EIF5-to-partner and partner-to-EIF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EIF5-low versus EIF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5→partner) and Y-score (partner→EIF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.424	-1.794	.006	.024	3	4
UCEC	HER3_pY1289 →	+0.068	+1.874	.020	.049	3	2
UCEC	JNK2 →	+0.233	+1.514	<.001	.015	3	2
UCEC	Caspase-8 →	-0.238	-2.636	.005	<.001	3	2
UCEC	14-3-3_beta →	-0.085	-2.295	.012	.005	3	1
UCEC	EGFR_pY1068 →	-0.287	-4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by EIF5 expression — UCEC

Explore this box plot interactively →