EIF5

Across TCGA cell cohorts, EIF5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible EIF5-associated genes across cancer lineages are TFAP2D, FEZF2, and OR13C5. Each is linked with EIF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF5-to-partner and partner-to-EIF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFAP2D grouped by EIF5-low versus EIF5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF5→partner) and Y-score (partner→EIF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TFAP2D →	+0.022	+4.930	<.001	.008	3	1
OVARY	FEZF2 →	+0.014	+4.990	<.001	.001	3	1
OVARY	OR13C5 →	+0.018	+5.339	<.001	<.001	3	1
OVARY	ZPBP →	+0.070	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TFAP2D by EIF5 expression — SOFT_TISSUE

Explore this box plot interactively →