EIF4G3

Across TCGA pan-cancer cohorts, EIF4G3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EIF4G3 data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher EIF4G3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF4G3 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where EIF4G3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	1.000	0.835	.032	6	view →
PDAC	OS	Median	All	0.293	0.457	.009	5	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.888	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

EIF4G3–COAD (DFS)

Open the COAD breakdown →