EIF4G3

Across TCGA patient cohorts, EIF4G3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,389 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible EIF4G3-associated genes across cancer lineages are ADAMTS12, MFAP2, and THY1. Each is linked with EIF4G3 in more than 5 cancer types. Because this analysis shows association rather than direction, both EIF4G3-to-partner and partner-to-EIF4G3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF4G3 versus ADAMTS12 in LSCC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G3→partner) and Y-score (partner→EIF4G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS12 →	+0.779	+0.188	<.001	<.001	3	6
OV	MFAP2 →	+1.371	+0.349	<.001	.002	3	5
GBM	THY1 →	+0.736	+0.198	<.001	.001	3	5
OV	HP1BP3 →	+0.722	+0.298	.003	.005	2	5
LSCC	SPON2 →	+0.980	+0.247	<.001	<.001	3	4
OV	OLFML2B →	+1.075	+0.362	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,389 associations by consensus.

EIF4G3 vs ADAMTS12 — LSCC

Explore this scatter interactively →