EIF4G3

Across TCGA patient cohorts, EIF4G3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4G3-associated genes across cancer lineages are PREX1, DJ-1, and PCNA. Each is linked with EIF4G3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF4G3-to-partner and partner-to-EIF4G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by EIF4G3-low versus EIF4G3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G3→partner) and Y-score (partner→EIF4G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PREX1 →	+0.208	+2.820	.042	.035	3	3
COAD	DJ-1 →	+0.202	+3.178	.027	.010	3	3
UCEC	PCNA →	+0.208	+1.678	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.224	+1.614	.002	.005	3	3
BLCA	p38-MAPK_pT180_Y182 →	-0.570	-1.807	<.001	.026	3	2
COAD	EGFR →	-0.187	-3.161	.037	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PREX1 by EIF4G3 expression — COAD

Explore this box plot interactively →