EIF4G3

Across TCGA cell cohorts, EIF4G3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,604 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF4G3-associated GO terms across cancer lineages are Regulation of translational initiation, Response to methionine, and Cellular response to methionine. Each is linked with EIF4G3 in more than 14 cancer types. Because this analysis shows association rather than direction, both EIF4G3-to-partner and partner-to-EIF4G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by EIF4G3-low versus EIF4G3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G3→partner) and Y-score (partner→EIF4G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of translational initiation →	+0.083	+1.205	.001	<.001	3	15
PANCREAS	Response to methionine →	+0.103	+1.017	.001	.001	3	15
PANCREAS	Cellular response to methionine →	+0.103	+1.017	.001	.001	3	15
PANCREAS	Regulation of organelle assembly →	+0.044	+1.076	<.001	.001	3	14
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.065	+0.635	<.001	.001	3	14
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.121	+0.681	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,604 associations by consensus.

Regulation of translational initiation by EIF4G3 expression — STOMACH

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