EIF4G3

Across TCGA cell cohorts, EIF4G3 mutation is significantly associated with the RNA expression of many other genes, with 761 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF4G3-associated genes across cancer lineages are GPR101, PRAMEF20, and SLC35D2. Each is linked with EIF4G3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4G3-to-partner and partner-to-EIF4G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by EIF4G3-low versus EIF4G3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G3→partner) and Y-score (partner→EIF4G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR101 →	+0.070	+4.906	<.001	.006	3	2
LUNG_SCLC	PRAMEF20 →	+0.250	+3.684	<.001	.001	3	2
LARGE_INTESTINE	SLC35D2 →	-0.898	-2.657	<.001	.002	3	2
LARGE_INTESTINE	NTN5 →	+0.302	+2.043	.005	.008	3	2
LARGE_INTESTINE	EAF1 →	+0.421	+2.043	.006	.008	3	2
LARGE_INTESTINE	GINS4 →	+0.722	+3.321	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 761 associations by consensus.

GPR101 by EIF4G3 expression — OESOPHAGUS

Explore this box plot interactively →