EIF4G2

Across TCGA cell cohorts, EIF4G2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF4G2-associated genes across cancer lineages are MBD3L3, CCL13, and OR7G2. Each is linked with EIF4G2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4G2-to-partner and partner-to-EIF4G2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by EIF4G2-low versus EIF4G2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G2→partner) and Y-score (partner→EIF4G2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MBD3L3 →	+0.020	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	CCL13 →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR7G2 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRLH →	+0.156	+5.228	<.001	.005	3	1
BLOOD_Leukemia	PNLIP →	+0.026	+4.539	<.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MBD3L3 by EIF4G2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →