EIF4G1

Across TCGA pan-cancer cohorts, EIF4G1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EIF4G1 data layer compared with 22 for mass-spec protein and 14 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EIF4G1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF4G1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where EIF4G1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.291	0.518	<.001	33	view →
CCRCC	DFS	Quartile	All	0.559	0.905	.001	25	view →
GBM	DFS	Quartile	All	0.244	0.469	.004	9	view →
HNSC	DFS	Tertile	II,III,IV	0.991	0.896	.022	7	view →
LUAD	DFS	Quartile	All	0.616	1.000	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EIF4G1–PDAC (DFS)

Open the PDAC breakdown →