EIF4G1

Across TCGA patient cohorts, EIF4G1 mutation is significantly associated with the RNA expression of many other genes, with 4,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4G1-associated genes across cancer lineages are MRPL18, ATP5MC1, and WNT4. Each is linked with EIF4G1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EIF4G1-to-partner and partner-to-EIF4G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL18 grouped by EIF4G1-low versus EIF4G1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G1→partner) and Y-score (partner→EIF4G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPL18 →	+0.337	+2.250	.007	.005	3	4
UCEC	ATP5MC1 →	+0.319	+2.091	.001	<.001	3	4
UCEC	WNT4 →	-0.668	-2.438	<.001	<.001	3	4
UCEC	PLB1 →	-0.348	-1.613	.001	<.001	3	4
UCEC	CHAF1A →	+0.511	+1.645	<.001	<.001	3	4
UCEC	CX3CR1 →	-0.447	-2.416	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,786 associations by consensus.

MRPL18 by EIF4G1 expression — SKCM

Explore this box plot interactively →