EIF4G1

Across TCGA patient cohorts, EIF4G1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4G1-associated genes across cancer lineages are ATM, EGFR_pY1068, and Caspase-7-cleavedD198. Each is linked with EIF4G1 in more than 4 cancer types. Because this analysis shows association rather than direction, both EIF4G1-to-partner and partner-to-EIF4G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EIF4G1-low versus EIF4G1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G1→partner) and Y-score (partner→EIF4G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.495	-1.678	<.001	<.001	3	5
UCEC	EGFR_pY1068 →	-0.191	-1.321	.006	.005	3	5
COAD	Caspase-7-cleavedD198 →	+1.552	+3.186	<.001	.009	3	4
STAD	PKC-b-II_pS660 →	-0.403	-3.700	.006	.001	2	5
STAD	TIGAR →	+0.412	+2.321	.016	.032	3	4
STAD	Bad_pS112 →	-0.304	-3.459	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ATM by EIF4G1 expression — UCEC

Explore this box plot interactively →