EIF4G1

Across TCGA cell cohorts, EIF4G1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,675 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF4G1-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, Transcription initiation at RNA polymerase I promoter, and Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with EIF4G1 in more than 14 cancer types. Because this analysis shows association rather than direction, both EIF4G1-to-partner and partner-to-EIF4G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by EIF4G1-low versus EIF4G1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G1→partner) and Y-score (partner→EIF4G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.181	+0.787	<.001	<.001	3	15
BONE	Transcription initiation at RNA polymerase I promoter →	+0.115	+0.617	<.001	.004	3	15
LARGE_INTESTINE	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.127	+0.682	<.001	<.001	3	14
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.131	+0.862	<.001	<.001	3	14
BONE	Regulation of DNA-templated DNA replication →	+0.135	+0.790	.006	.001	3	14
LARGE_INTESTINE	rRNA 5'-end processing →	+0.127	+0.682	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,675 associations by consensus.

Positive regulation of mitotic cytokinesis by EIF4G1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →