EIF4G1

Across TCGA cell cohorts, EIF4G1 mutation is significantly associated with the RNA expression of many other genes, with 1,780 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF4G1-associated genes across cancer lineages are POLDIP3, KCND1, and AKAP10. Each is linked with EIF4G1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF4G1-to-partner and partner-to-EIF4G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLDIP3 grouped by EIF4G1-low versus EIF4G1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4G1→partner) and Y-score (partner→EIF4G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLDIP3 →	+0.498	+1.678	.001	.002	3	3
LARGE_INTESTINE	KCND1 →	+0.394	+3.321	.009	.002	3	3
LARGE_INTESTINE	AKAP10 →	+0.622	+1.891	<.001	<.001	3	3
LARGE_INTESTINE	PAPOLG →	+0.404	+2.652	<.001	.001	3	3
LARGE_INTESTINE	SLC25A28 →	+0.418	+2.182	<.001	.001	3	3
LARGE_INTESTINE	AMFR →	+0.390	+2.700	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,780 associations by consensus.

POLDIP3 by EIF4G1 expression — LARGE_INTESTINE

Explore this box plot interactively →