EIF4EP3

Across TCGA pan-cancer cohorts, EIF4EP3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of EIF4EP3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where EIF4EP3 RNA is repressed in tumor relative to normal tissue. In most cancer types EIF4EP3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, HNSC, and PRAD are the cancer types where EIF4EP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF4EP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.052	.008	4	view →
HNSC	Male	All	+0.065	.037	2	view →
PRAD	All	All	+0.028	.022	2	view →
BRCA	Female	All	+0.014	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

EIF4EP3–THCA

Open the THCA breakdown →