Across TCGA pan-cancer cohorts, EIF4ENIF1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EIF4ENIF1 data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF4ENIF1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated EIF4ENIF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, LIHC, and KICH are the cancer types where EIF4ENIF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.973	0.826	.010	24	view →
LIHC	OS	Median	All	0.409	0.778	.003	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	III,IV	0.087	0.616	<.001	12	view →
COAD	DFS	Median	III,IV	0.154	0.616	.029	6	view →
LUSC	DFS	Median	All	0.887	0.383	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: EIF4ENIF1 tumor-vs-normal RNA expression · all EIF4ENIF1 data types