Across TCGA pan-cancer cohorts, EIF4ENIF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated EIF4ENIF1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF4ENIF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EIF4ENIF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where EIF4ENIF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.837	0.958	.006	32	view →
LSCC	OS	Tertile	All	0.878	0.667	.021	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.959	0.222	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: EIF4ENIF1 tumor-vs-normal RNA expression · all EIF4ENIF1 data types