Across TCGA patient cohorts, EIF4ENIF1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4ENIF1-associated genes across cancer lineages are eIF4E, Notch1, and p21. Each is linked with EIF4ENIF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF4ENIF1-to-partner and partner-to-EIF4ENIF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4ENIF1→partner) and Y-score (partner→EIF4ENIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.215	+2.201	.002	<.001	3	3
UCEC	Notch1 →	+0.131	+1.584	.005	.009	3	3
COAD	p21 →	+0.273	+2.364	.005	.018	3	3
UCEC	PCNA →	+0.296	+2.584	<.001	<.001	3	3
UCEC	TFRC →	+0.578	+3.584	.001	.002	3	3
COAD	ATM →	-0.816	-3.450	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

EIF4ENIF1 survival (RNA) · tumor vs normal (RNA) · all EIF4ENIF1 data types