EIF4EBP3

Across TCGA pan-cancer cohorts, EIF4EBP3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated EIF4EBP3 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher EIF4EBP3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EIF4EBP3 expression acts as an unfavorable survival marker, although some lineages such as ACC and HNSC show a favorable association.

ACC, HNSC, and UVM are the cancer types where EIF4EBP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.803	0.344	<.001	121	view →
HNSC	DFS	Median	IV	0.729	0.553	<.001	96	view →
UVM	DFS	Quartile	All	0.420	0.870	<.001	94	view →
MESO	OS	Median	II,III,IV	0.530	0.272	<.001	80	view →
READ	DFS	Median	All	0.867	0.562	.005	54	view →
BRCA	OS	Median	III,IV	0.954	0.855	<.001	53	view →
SCLC	OS	Tertile	II,III,IV	0.370	0.735	.001	48	view →
SARC	OS	Median	All	0.883	0.788	<.001	33	view →
KIRC	OS	Median	All	0.746	0.559	<.001	24	view →
CHOL	DFS	Quartile	All	0.701	0.238	.006	19	view →
ESCA	OS	Tertile	IV	0.247	0.922	.024	12	view →
PAAD	OS	Median	All	0.363	0.630	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

EIF4EBP3–ACC (OS)

Open the ACC breakdown →