EIF4EBP3

Across TCGA pan-cancer cohorts, EIF4EBP3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated EIF4EBP3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EIF4EBP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EIF4EBP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC and CCRCC are the cancer types where EIF4EBP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.828	0.973	.007	6	view →
CCRCC	OS	Median	All	0.983	0.901	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

EIF4EBP3–LSCC (OS)

Open the LSCC breakdown →