EIF4EBP2

Across TCGA patient cohorts, EIF4EBP2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4EBP2-associated genes across cancer lineages are HNRNPCL4, RNU6-444P, and MIR188. Each is linked with EIF4EBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4EBP2-to-partner and partner-to-EIF4EBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPCL4 grouped by EIF4EBP2-low versus EIF4EBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4EBP2→partner) and Y-score (partner→EIF4EBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HNRNPCL4 →	+0.052	+4.442	<.001	.007	3	1
UCEC	RNU6-444P →	+0.913	+4.148	<.001	.004	3	1
UCEC	MIR188 →	+0.347	+4.997	.001	.003	3	1
UCEC	SNORD90 →	+0.650	+3.840	<.001	.007	3	1
UCEC	NPAP1P2 →	+0.057	+3.871	<.001	.006	3	1
UCEC	MIR1180 →	+0.843	+4.061	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

HNRNPCL4 by EIF4EBP2 expression — UCEC

Explore this box plot interactively →