Across TCGA pan-cancer cohorts, EIF4EBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EIF4EBP1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EIF4EBP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EIF4EBP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where EIF4EBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.885	1.000	.002	96	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.270	<.001	32	view →
LUAD	OS	Median	All	0.884	1.000	.002	21	view →
LSCC	OS	Tertile	III,IV	0.419	0.839	.014	14	view →
HNSC	DFS	Median	III,IV	0.512	0.712	.015	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: EIF4EBP1 tumor-vs-normal RNA expression · all EIF4EBP1 data types