Across TCGA pan-cancer cohorts, EIF4EBP1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of EIF4EBP1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where EIF4EBP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EIF4EBP1 is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

CCRCC, PDAC, and LUAD are the cancer types where EIF4EBP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF4EBP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.939	<.001	12	view →
PDAC	Male	II,III,IV	−0.454	<.001	6	view →
LUAD	All	All	−0.108	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: EIF4EBP1 RNA expression & survival · all EIF4EBP1 data types