EIF4E3

Across TCGA patient cohorts, EIF4E3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E3-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and p27_pT198. Each is linked with EIF4E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E3-to-partner and partner-to-EIF4E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EIF4E3-low versus EIF4E3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E3→partner) and Y-score (partner→EIF4E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.819	+2.827	.011	.035	3	2
UCEC	Notch1 →	+0.337	+3.013	<.001	.018	3	1
UCEC	p27_pT198 →	+0.150	+3.169	.010	.020	3	1
UCEC	p62 Lck ligand →	+0.486	+3.009	.006	.019	3	1
UCEC	STAT3_pY705 →	-0.401	-3.169	.005	.020	3	1
UCEC	ATM →	-0.927	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by EIF4E3 expression — UCEC

Explore this box plot interactively →