EIF4E3

Across TCGA cell cohorts, EIF4E3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,983 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF4E3-associated GO terms across cancer lineages are Response to topologically incorrect protein, Cellular response to topologically incorrect protein, and Vesicle targeting, rough ER to cis-Golgi. Each is linked with EIF4E3 in more than 11 cancer types. Because this analysis shows association rather than direction, both EIF4E3-to-partner and partner-to-EIF4E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to topologically incorrect protein grouped by EIF4E3-low versus EIF4E3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E3→partner) and Y-score (partner→EIF4E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Response to topologically incorrect protein →	+0.062	+0.971	.005	.001	2	12
OESOPHAGUS	Cellular response to topologically incorrect protein →	+0.079	+0.879	.003	.006	3	10
URINARY_TRACT	Vesicle targeting, rough ER to cis-Golgi →	+0.098	+1.173	<.001	.002	2	11
OESOPHAGUS	Endoplasmic reticulum unfolded protein response →	+0.065	+0.949	.006	<.001	3	10
STOMACH	Macroautophagy →	+0.070	+1.471	.001	<.001	3	9
OESOPHAGUS	ER-nucleus signaling pathway →	+0.129	+0.997	.003	.005	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,983 associations by consensus.

Response to topologically incorrect protein by EIF4E3 expression — SKIN

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