EIF4E3

Across TCGA cell cohorts, EIF4E3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF4E3-associated genes across cancer lineages are OR2M5 and MINDY4B. Each is linked with EIF4E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E3-to-partner and partner-to-EIF4E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by EIF4E3-low versus EIF4E3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E3→partner) and Y-score (partner→EIF4E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	MINDY4B →	+0.036	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR2M5 by EIF4E3 expression — LARGE_INTESTINE

Explore this box plot interactively →