EIF4E2

Across TCGA pan-cancer cohorts, EIF4E2 mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated EIF4E2 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EIF4E2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EIF4E2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, COAD, and OV are the cancer types where EIF4E2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	IV	0.934	0.395	.024	7	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
OV	DFS	Quartile	All	0.543	0.884	.026	4	view →
GBM	OS	Quartile	All	0.856	0.997	.044	4	view →
UCEC	OS	Median	All	0.961	0.860	.037	4	view →
LUAD	DFS	Median	All	0.563	0.893	.042	2	view →
LSCC	OS	Quartile	All	0.761	0.934	.028	2	view →
HNSC	DFS	Quartile	III,IV	0.629	0.924	.015	2	view →
CCRCC	DFS	Quartile	All	0.791	0.340	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

EIF4E2–PDAC (OS)

Open the PDAC breakdown →