EIF4E2

Across TCGA patient cohorts, EIF4E2 mutation is significantly associated with the RNA expression of many other genes, with 1,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E2-associated genes across cancer lineages are LINC00380, RN7SL478P, and MIR4274. Each is linked with EIF4E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E2-to-partner and partner-to-EIF4E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00380 grouped by EIF4E2-low versus EIF4E2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E2→partner) and Y-score (partner→EIF4E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC00380 →	+0.218	+5.632	<.001	.001	3	2
UCEC	RN7SL478P →	+0.184	+1.868	.001	.002	3	2
COAD	MIR4274 →	+0.536	+7.741	<.001	.009	3	2
BRCA	TTTY7B →	+0.024	+8.471	<.001	.005	3	1
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	1
LUAD	OR1M1 →	+0.096	+4.426	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,130 associations by consensus.

LINC00380 by EIF4E2 expression — BLCA

Explore this box plot interactively →