EIF4E2

Across TCGA patient cohorts, EIF4E2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E2-associated genes across cancer lineages are 14-3-3_beta, JNK2, and Lck. Each is linked with EIF4E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E2-to-partner and partner-to-EIF4E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EIF4E2-low versus EIF4E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E2→partner) and Y-score (partner→EIF4E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-1.893	.006	.016	3	1
UCEC	JNK2 →	+0.189	+3.469	.017	.002	3	1
UCEC	Lck →	+0.236	+2.999	.003	.035	3	1
UCEC	PKC-a →	+0.321	+2.335	.048	.018	3	1
UCEC	Shc_pY317 →	-0.208	-2.700	<.001	.006	3	1
UCEC	Caspase-7-cleavedD198 →	+0.925	+2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

14-3-3_beta by EIF4E2 expression — UCEC

Explore this box plot interactively →