EIF4E2

Across TCGA cell cohorts, EIF4E2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,046 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF4E2-associated GO terms across cancer lineages are Protein-RNA covalent cross-linking repair, Protein depolymerization, and Regulation of protein sumoylation. Each is linked with EIF4E2 in more than 13 cancer types. Because this analysis shows association rather than direction, both EIF4E2-to-partner and partner-to-EIF4E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-RNA covalent cross-linking repair grouped by EIF4E2-low versus EIF4E2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E2→partner) and Y-score (partner→EIF4E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-RNA covalent cross-linking repair →	+0.133	+0.494	<.001	.004	3	14
PANCREAS	Protein depolymerization →	+0.084	+0.487	.002	<.001	3	11
LARGE_INTESTINE	Regulation of protein sumoylation →	+0.102	+0.505	.001	.006	2	11
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.078	+1.027	<.001	<.001	3	10
OVARY	Response to dehydroepiandrosterone →	+0.186	+0.693	<.001	<.001	3	10
CNS	COP9 signalosome assembly →	+0.121	+0.529	<.001	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,046 associations by consensus.

Protein-RNA covalent cross-linking repair by EIF4E2 expression — LUNG_SCLC

Explore this box plot interactively →