EIF4E2

Across TCGA cell cohorts, EIF4E2 mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF4E2-associated genes across cancer lineages are 5-Fluorouracil, GSK2801, and AGI-6780. Each is linked with EIF4E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E2-to-partner and partner-to-EIF4E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5-Fluorouracil grouped by EIF4E2-low versus EIF4E2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E2→partner) and Y-score (partner→EIF4E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	5-Fluorouracil →	+0.602	+2.769	.038	.040	3	1
LARGE_INTESTINE	GSK2801 →	+0.333	+2.678	.036	.037	3	1
LARGE_INTESTINE	AGI-6780 →	+0.396	+2.646	.041	.047	3	1
LARGE_INTESTINE	729189 →	+0.256	+2.649	.045	.046	2	1
LARGE_INTESTINE	EPZ004777 →	+0.313	+2.893	.049	.034	1	1
LARGE_INTESTINE	CZC24832 →	+0.262	+2.646	.044	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

5-Fluorouracil by EIF4E2 expression — LARGE_INTESTINE

Explore this box plot interactively →