EIF4E

Across TCGA pan-cancer cohorts, EIF4E Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EIF4E data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher EIF4E Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated EIF4E expression acts as an unfavorable survival marker.

KIRP, UCEC, and ACC are the cancer types where EIF4E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.157	0.704	.005	12	view →
UCEC	OS	Median	IV	0.133	0.754	<.001	12	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LIHC	OS	Median	All	0.188	0.669	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EIF4E–KIRP (OS)

Open the KIRP breakdown →