EIF4E

Across TCGA patient cohorts, EIF4E RNA expression is significantly associated with the protein abundance of many other proteins, with 13,626 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EIF4E-associated proteins across cancer lineages are G3BP2, SEC24B, and GSTCD. Each is linked with EIF4E in more than 4 cancer types. Because this analysis shows association rather than direction, both EIF4E-to-partner and partner-to-EIF4E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF4E versus G3BP2 in PDAC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E→partner) and Y-score (partner→EIF4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	G3BP2 →	+0.186	+0.301	<.001	.001	3	5
OV	SEC24B →	+0.172	+0.424	<.001	<.001	3	4
BRCA	GSTCD →	+0.373	+0.556	<.001	<.001	3	4
OV	ANKRD17 →	+0.540	+0.698	<.001	<.001	3	4
COAD	NAA10 →	+0.248	+0.461	<.001	<.001	3	4
LSCC	NAA15 →	+0.298	+0.405	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,626 associations by consensus.

EIF4E vs G3BP2 — PDAC

Explore this scatter interactively →