EIF4E

Across TCGA patient cohorts, EIF4E protein abundance is significantly associated with the RNA expression of many other genes, with 9,463 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E-associated genes across cancer lineages are PAICS, PPAT, and RAP1GDS1. Each is linked with EIF4E in more than 5 cancer types. Because this analysis shows association rather than direction, both EIF4E-to-partner and partner-to-EIF4E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF4E versus PAICS in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E→partner) and Y-score (partner→EIF4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PAICS →	+0.690	+0.186	<.001	<.001	3	5
LSCC	PPAT →	+0.610	+0.154	<.001	<.001	3	5
BRCA	RAP1GDS1 →	+0.463	+0.145	<.001	.001	3	5
UCEC	NUP54 →	+0.560	+0.171	.002	<.001	3	5
BRCA	CCNA2 →	+0.851	+0.218	.003	.005	3	5
GBM	TAL1 →	-0.595	-0.122	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,463 associations by consensus.

EIF4E vs PAICS — LSCC

Explore this scatter interactively →