EIF4E

Across TCGA patient cohorts, EIF4E mutation is significantly associated with the RNA expression of many other genes, with 1,528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E-associated genes across cancer lineages are MRPS17P3, RN7SL354P, and RNU6-709P. Each is linked with EIF4E in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E-to-partner and partner-to-EIF4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS17P3 grouped by EIF4E-low versus EIF4E-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E→partner) and Y-score (partner→EIF4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MRPS17P3 →	+0.132	+4.653	<.001	.004	3	2
CESC	RN7SL354P →	+0.166	+4.653	<.001	.004	3	2
CESC	RNU6-709P →	+0.337	+7.174	<.001	<.001	3	2
COAD	RNA5SP334 →	+0.431	+6.547	<.001	.001	3	2
COAD	OOSP4B →	+0.115	+6.721	<.001	<.001	3	2
STAD	RNU6-72P →	+0.780	+5.274	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,528 associations by consensus.

MRPS17P3 by EIF4E expression — CESC

Explore this box plot interactively →