EIF4E

Across TCGA patient cohorts, EIF4E mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF4E-associated genes across cancer lineages are Ku80, PKC-a_pS657, and Annexin-1. Each is linked with EIF4E in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF4E-to-partner and partner-to-EIF4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by EIF4E-low versus EIF4E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4E→partner) and Y-score (partner→EIF4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.300	+2.179	.003	.034	3	1
UCEC	PKC-a_pS657 →	+0.338	+2.179	.042	.034	3	1
UCEC	Annexin-1 →	+0.544	+3.189	.018	.010	3	1
UCEC	Shc_pY317 →	-0.161	-3.321	.015	.010	3	1
UCEC	VHL →	-0.771	-2.115	.009	.019	3	1
UCEC	Collagen-VI →	-0.277	-3.308	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by EIF4E expression — UCEC

Explore this box plot interactively →